MAZ - A REVOLUTIONARY MIXER

 Anesthetic. Treats pain by blocking electrical signals in the brain and spine.

 Tricyclic antidepressant. Inhibits serotonin reuptake, suppressing pain signals in the central nervous system.

 Muscle relaxant / antispasmodic. Helps reduce pain by relaxing muscles. Since topical use causes much less systemic absorption, the typical side effects (drowsiness, increased urination, mental confusion, constipation and fatigue) are usually not seen.

 Local anesthetic. Can be used to treat neuropathic pain by blocking nerve signals.

 Antihypertensive. Used to treat neuropathic pain.

 Muscle relaxant. Helps control muscle spasms and tightness. A common side effect of this medication when taken orally is drowsiness, but this risk is reduced with transdermal medication.

 Anti-inflammatory (NSAID). Helps reduce inflammation and pain. Transdermal application reduces the risk of side effects, such as GI upset, and lowers the possibility of stomach ulceration. The FDA requests that physicians measure liver function periodically in patients receiving long-term therapy with diclofenac.

  Anti-inflammatory (NSAID). Reduces pain, inflammation, and fever. Commonly used to treat arthritis pain.

 Anticonvulsant. Works by three mechanisms to treat neuropathic pain (pain typically caused by damaged or misfiring nerve fibers). Best combined with ketamine for maximum synergistic effect.

 Tricyclic antidepressant. Treats neuropathic pain by acting on serotonin and norepinephrine in the nervous system.

  Anti-inflammatory (NSAID). Helps reduce hormones which cause inflammation and pain. There is extensive research on transdermal delivery of ketoprofen. 

  Topical Anesthetic. Helps reduce pain. The most common transdermal side effects are tingling and numbness at the site of application.